Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials† †Electronic supplementary information (ESI) available: Synthetic procedures; supplementary methods including NMR, OGFOD1/Tpa1a/OFD1/PHD2/FIH hydroxylation assays, cell culture and immunoblotting, RT-qPCR assays and cell viability assays; supplementary figures; supplementary tables. See DOI: 10.1039/c7sc02103h
نویسندگان
چکیده
Authors: Tzu-Lan Yeh 1,4 , Thomas M. Leissing 1,2 , Martine I. Abboud 1 , Cyrille C. Thinnes 1 , Onur Atasoylu 1 , James P. Holt-Martyn 1 , Dong Zhang 1 , Anthony Tumber 1,3 , Kerstin Lippl 1 , Christopher T. Lohans 1 , Ivanhoe K. H. Leung 1‡ , Helen Morcrette 5† , Ian J. Clifton 1 , Timothy D. W. Claridge 1 , Akane Kawamura 1,5 , Emily Flashman 1 , Xin Lu 2 , Peter J. Ratcliffe 4,6 , Rasheduzzaman Chowdhury 1 , Christopher W. Pugh 4 , and Christopher J. Schofield 1*
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2017